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Publications


Peer-Reviewed Publications | Invited Reviews | Book Chapters


Peer-Reviewed Publications

Davison I.G., and Ehlers M.D. (2011). Neural circuit mechanisms for pattern detection and feature combination in olfactory cortex. Neuron 70(1):82-94.

Kennedy M.J., Hughes R.M., Peteya L.A., Schwartz J.W., Ehlers M.D., and Tucker C.L. (2010). Rapid blue-light-mediated induction of protein interactions in living cells. Nature Methods 7(12):973-5.

Lee M.C., Yasuda R., and Ehlers M.D. (2010). Metaplasticity at single glutamatergic synapses. Neuron 66(6):859-70.

Yi J.J., Barnes A.P., Hand R., Polleux F., and Ehlers M.D. (2010). TGF-beta signaling specifies axons during brain development. Cell 142(1):144-57.

Kennedy M.J., Davison I.G., Robinson C.G., and Ehlers M.D. (2010). Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines. Cell 141(3):524-35.

Yashiro K., Riday T.T., Condon K.H., Roberts A.C., Bernardo D.R., Prakash R., Weinberg R.J., Ehlers M.D., and Philpot BD. (2009). Ube3a is required for experience-dependent maturation of the neocortex. Nature Neuroscience 12(6):777-83.

Helton T.D., Otsuka T., Lee M.C., Mu Y., and Ehlers M. D. (2008). Pruning and loss of excitatory synapses by the parkin ubiquitin ligase. Proc Natl Acad Sci U S A 105(49):19492-7.

Wang Z., Edwards J.G., Riley N., Provance D.W. Jr, Karcher R., Li X.D., Davison I.G., Ikebe M., Mercer J.A., Kauer J.A., and Ehlers M. D. (2008). Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity. Cell 135(3):535-48.

B. R. Arenkiel, M. E. Klein, I. G. Davison, L. C. Katz, and M. D. Ehlers (2008). Targeted genetic control of neuronal activity in mice conditionally expressing TRPV1. Nature Methods 5(4):299-302.

J. Lu, T. D. Helton, T. A. Blanpied, B. Racz, T. M. Newpher, R. J. Weinberg, and M. D. Ehlers (2007). Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to homer. Neuron 55(6):874-89.

I. E. Michailidis, T. D. Helton, V. I. Petrou, T. Mirshahi, M. D. Ehlers, D. E. Logothetis. (2007). Phosphatidylinositol-4,5-bisphosphate regulates NMDA receptor activity through alpha-actinin. J Neurosci. 27:5523-32.

M. D. Ehlers, M. Heine, L. Groc, M. C. Lee, D. Choquet. (2007). Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity. Neuron. 54:447-60.

B. R. Arenkiel, J. Peca, I. G. Davison, C. Feliciano, K. Disseroth, G. J. Augustine, M. D. Ehlers, G. Feng (2007). In vivo light-induced activation of neural circuitry in transgenic mice expressinf channelrhodopsin-2. Neuron. 54:205-18.

M. Park, J. M. Salgado, L. Ostroff, T. D. Helton, C. G. Robinson, K. M. Harris, M. D. Ehlers (2006). Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes. Neuron. 52:817-30.

A. C. Horton, J. J. Yi, and M. D. Ehlers (2006). Cell type-specific dendritic polarity in the absence of spatially organized external cues. Brain Cell Biol. 1:29-38

I. Perez-Otano, R. Lujan, S. J. Tavalin, M. Plomann, J. Modregger, X. B. Liu, E. G. Jones, S. F. Heinemann, D. C. Lo, M. D. Ehlers (2006). Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1. Nat Neurosci. 9:611-21.

H. S. Hoe, A. Pocivavsek, G. Chakraborty, Z. Fu, S. Vicini, M. D. Ehlers, G. W. Rebeck (2006). Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. J Biol Chem. 281:3425-31.

A. C. Horton, B. Racz, E. E. Monson, A. L. Lin, R. J. Weinberg, M. D. Ehlers (2005). Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis. Neuron 48(5):757-71.

I. K. Svenson, M. T. Kloos, A. Jacon, C Gallione, A. C. Horton, M. A. Pericak-Vance, M. D. Ehlers, D. A. Marchuk (2005). Subcellular localization of spastin: implications for the pathogenesis of hereditary spastic paraplegia. Neurogenetics 6(3):135-41.

R. T. Terry-Lorenzo, D. W. Roadcap, T. Otsuka, T. A. Blanpied, P. Zamorano, C. C. Garner, S. Shenolikar, and M. D. Ehlers (2005). Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. Mol. Biol. Cell 16:2349-2362.

M. Park, E. C. Penick, J. G. Edwards, J. A. Kauer, and M. D. Ehlers (2004). Recycling endosomes supply AMPA receptors for LTP. Science 305:1972-1975.

B. Racz, T. A. Blanpied, **M.D. Ehlers, and R. J. Weinberg (2004). Lateral organization of endocytic machinery in dendritic spines. Nature Neurosci. 7:917-918. **Corresponding author.

D. B. Scott, I. Michailidis, Y. Mu, D. Logothetis, and M. D. Ehlers (2004). Endocytosis and degradative sorting of NMDA receptors by conserved membrane-proximal signals. J. Neurosci. 24: 7096-7109.

T. A. Blanpied, D. B. Scott, and M. D. Ehlers (2003). Age-related regulation of dendritic endocytosis associated with altered clathrin dynamics. Neurobiol. Aging 24:1095-1104.

Y. Mu, T. Otsuka, A. C. Horton, D. B. Scott, and M. D. Ehlers (2003). Activity-dependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors. Neuron 40:581-594.

D. B. Scott, T. A. Blanpied, and M. D. Ehlers (2003). Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors. Neuropharm. 45:755-767.

A. C. Horton and M. D. Ehlers (2003). Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging. J. Neurosci. 23: 6188-6199.

M.D. Ehlers (2003). Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system. Nature Neurosci. 6:231-242.

T.A. Blanpied, D.B. Scott, and M.D. Ehlers (2002). Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines. Neuron 36:435-449.

K. W. Roche, S. Standley, J. McCallum, C. D. Ly, M. D. Ehlers, and R. J. Wenthold (2001). Molecular determinants of NMDA receptor internalization. Nature Neurosci. 4:794-802

D. B. Scott, T. A. Blanpied, G. T. Swanson, C. Zhang, and M. D. Ehlers (2001). An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J. Neurosci. 21:3063-3072.

M. D. Ehlers (2000). Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting. Neuron 28:511-525.

D. Liao, X. Zhang, R. J. O’Brien, M. D. Ehlers, and R. L. Huganir (1999). Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons. Nature Neurosci. 2:37-43.

M. D. Ehlers, E. T. Fung, R. J. O’Brien, and R. L. Huganir (1998). Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments. J. Neurosci. 18(2):720-730.

**S. Zhang, **M. D. Ehlers, J. P. Bernhardt, and R. L. Huganir (1998). Calmodulin mediates calcium-dependent desensitization of NMDA receptors. Neuron 21:443-453. **Equally contributing authors.

R. J. O’Brien, S. Kamboj, M. D. Ehlers, D. Liao, K. R. Rosen, G. D. Fischbach, and R. L. Huganir (1998). Activity-dependent modulation of synaptic AMPA receptor accumulation. Neuron 21:1067-1078.

R. J. O’Brien, A. L. Mammen, S. Blackshaw, M. D. Ehlers, J. D. Rothstein, and R. L. Huganir (1997). The development of excitatory synapses in cultured rat spinal neurons. J. Neurosci. 17(19):7339-7350.

W. G. Tingley, M. D. Ehlers, K. Kameyama, C. Doherty, J. B. Ptak, C. T. Riley, and R. L. Huganir (1997). Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J. Biol. Chem. 272:5157-5166.

M. D. Ehlers, S. Zhang, J. P. Bernhardt, and R. L. Huganir (1996). Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit. Cell 84:745-755.

L.-F. Lau, A. L. Mammen, M. D. Ehlers, S. Kindler, W. J. Chung, C. C. Garner, and R. L. Huganir (1996). Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102. J. Biol. Chem. 271:21622-21628.

U. Scheffel, C. Steinert, S. E. Kim, M. D. Ehlers, J. W. Boja, and M. J. Kuhar (1996). Effect of dopaminergic drugs on the in vivo binding of [3H]WIN 35,428 to central dopamine transporters. Synapse 23:61-69.

M. D. Ehlers, W. G. Tingley, and R. L. Huganir (1995). Regulated subcellular distribution of the NR1 subunit of the NMDA receptor. Science 269:1734-1737.

M. D. Ehlers, D. R. Kaplan, D. L. Price, and V. E. Koliatsos (1995). NGF-stimulated retrograde transport of trkA in the mammalian nervous system. J. Cell Biol. 130:149-156.

J. J. Frost, A. J. Rosier, S. G. Reich, J. S. Smith, M. D. Ehlers, S. H. Snyder, H. T. Raver, and R. F. Dannals (1993). Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. Ann. Neurol. 34:423-431.


Invited Reviews

M.J. Kennedy and M. D. Ehlers (2011). Mechanisms and function of dendritic exocytosis. Neuron 69(5):856-75.

A.M. Mabb and M. D. Ehlers (2010). Ubiquitination in postsynaptic function and plasticity. Annu Rev Cell Dev Biol. 26:179-210.

B.R. Arenkiel and M. D. Ehlers (2009). Molecular genetics and imaging technologies for circuit-based neuroanatomy. Nature 461(7266):900-7.

T.M. Newpher and M. D. Ehlers (2009). Spine microdomains for postsynaptic signaling and plasticity. Trends Cell Biology 19(5):218-27.

C. Hanus and M. D. Ehlers (2008). Secretory outposts for the local processing of membrane cargo in neuronal dendrites. Traffic 9(9):1437-45.

T.M. Newpher and M. D. Ehlers (2008). Glutamate receptor dynamics in dendritic microdomains. Neuron 58(4):472-97.

M. D. Ehlers (2007). Secrets of the secretory pathway in dendrite growth. Neuron 55:686-689.

J. J. Yi and M. D. Ehlers (2007). Emerging roles for ubiquitin and protein degradation in neuronal function. Pharmacol Rev. 59:14-39.

M. J. Kennedy and M. D. Ehlers (2006). Organelles and trafficking machinery for postsynaptic plasticity. Annu Rev Neurosci. 29:325-62.

J. J. Yi and M. D. Ehlers (2005). Targeting protein degradation in the nervous system. Curr. Med. Chem. – Central Nervous System Agents 5:285-306.

J. J. Yi and M. D. Ehlers (2005). Ubiquitin and Protein Turnover in Synapse Function. Neuron, 47(5):629-32

I. Perez-Otano and M. D. Ehlers (2005). Homeostatic plasticity and NMDA receptor trafficking. Trends Neurosci. 28:229-238.

M. D. Ehlers (2005). Dendrite development: a surprising origin. J Cell Biol. 170:517-9.

M. D. Ehlers (2005). Synapse formation: astrocytes spout off. Curr Biol. 15:R134-147.

A. C. Horton and M. D. Ehlers (2004). Secretory trafficking in neuronal dendrites. Nature Cell Biol. 6:585-591.

T. A. Blanpied and M. D. Ehlers (2004). The microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric disease. Biol. Psychiatry 55:1121-1127.

I. Perez-Otano and M. D. Ehlers (2004). Learning from NMDA receptor trafficking: Clues to the development and maturation of glutamatergic synapses. Neurosignals 13:175-189.

M. D. Ehlers (2004). Deconstructing the axon: Wallerian degeneration and the ubiquitin-proteasome system. Trends Neurosci. 27(1):3-6.

M. D. Ehlers (2003). Ubiquitin and the deconstruction of synapses. Science 302:800-801.

A. C. Horton and M. D. Ehlers (2003). Neuronal polarity and trafficking. Neuron 40:.277-295.

M. D. Ehlers (2003). Ubiquitin and synaptic dysfunction. Trends Neurosci. 26:4-7.

M. D. Ehlers (2002). Molecular morphogens for dendritic spines. Trends Neurosci. 25:64-67.

M. D. Ehlers and G. Feng (2001). Good communications: A review of Synapses. Nature 411:416-417

M. M. Bolton, T. A. Blanpied, and M. D. Ehlers (2000) Localization and stabilization of ionotropic glutamate receptors at synapses. Cell. Mol. Life Sci.57:1517-1525.

M. D. Ehlers (1999) Glutamate receptors connected by the shanks. Curr. Biol. 9:R848-R850.

M. D. Ehlers and G. J. Augustine (1999). Calmodulin at the channel gate. Nature 399:105-107.

M. D. Ehlers, A. L. Mammen, L-F. Lau, and R. L. Huganir (1996). Synaptic targeting of glutamate receptors. Curr. Opin. Cell Biol. 8:484-489


Book Chapters

C. Hanus and M. D. Ehlers (2008). Dendritic organelles for postsynaptic trafficking. Structural and Functional Organization of the Synapse, M. D. Ehlers and J. W. Hell (eds), Springer (in press).

T. D. Helton and M. D. Ehlers (2008): Ubiquitin and protein degradation in synapse function. Structural and Functional Organization of the Synapse, M. D. Ehlers and J. W. Hell (eds), Springer (in press).

K. H. Condon and M. D. Ehlers (2007). Postsynaptic Machinery for Receptor Trafficking. Protein Trafficking in Neurons, A. J. Bean (ed), Elsevier Academic Press, London.

D. B. Scott and M. D. Ehlers (2004). Glutamate Receptors, Ionotropic. The Encyclopedia of Biological Chemistry, William Lennarz and M. Daniel Lane (eds), Academic Press, San Diego.